Association of single nucleotide variants rs34532313 of the <i>MTNR1A</i> gene and rs10830963 of the <i>MTNR1B</i> gene with suicidal risk in alcohol dependence syndrome and insomnia

Background : Suicidal behaviour is the leading cause of mortality from external causes at all ages worldwide. More than a million people commit completed suicide each year. According to World Health Organisation, 25-50% victims suffered alcohol and other substance use disorders, 22% deaths were attributable (WHO, 2014). Several papers have suggested potential associations insomnia increased risk in patients with alcoholism. We hypothesise that mutations melatonin receptor genes may be associated Methods . The Insomnia Severity Index (ISI) was used as tool assess presence severity insomnia. Columbia Suicide Rating Scale (C-SSRS) method examine suicidal behavior. Genotyping MTNR1A (rs34532313), MTNR1B (rs10830963) performed using real-time polymerase chain reaction (RT-PCR). A comparative genetic study two groups carried out: first group, dependence syndrome (F10.2); second (F10.2) insomnia, which persisted 7-14 days after starting withdrawal therapy. Results. thoughts history auto-aggressive more common subjects post-withdrawal period. Carriers TT genotype gene (rs34532313) likely attempts Conclusions. Our found marker However, same pattern not observed without